Benign Pancreatic Hyperenzinemia - Gullo's Syndrome

Abstract

Benign pancreatic hyperenzynemia, also known as Gullo’s syndrome, is a syndrome first described in 1996 by Lucio Gullo which is characterized by an abnormal increase of serum pancreatic enzyme in absence of pancreatic disease. We describe the case of a 62-year-old patient who was found to have significant elevation of amylase levels while she was asymptomatic. Laboratory and imaging tests were performed to determine the etiology, but they gave normal results. The enzyme elevation can be only one enzyme may elevate, although most often all pancreatic enzymes (amilase, isoamilase and/or lipase) are elevated. The etiology is not known. This enzyme elevation is described both in children and adult and sporadically or with a familial pattern. Its knowledge allows us to confirm a benign prognosis about it and reassure and that in the end it will not require aggressive treatments such as surgery or chemotherapy.